Vol. 168 No. 23

COVER

How Americans Are Living Dangerously (Science)
We worry too much about overhyped threats, and ignore the things that really put us at risk

The Year In Medicine From A to Z (Cover Story / The Year In Medicine)
It was a year of old scourges and new drugs, from the first vaccine that prevents cancer to a bug that spoiled an entire crop of California spinach

NATION

When the Democrats Take Back K Street
Democratic lobbyists are enjoying a comeback after 12 years of exile. Never mind those promised reforms

A Mormon as President?
Mitt Romney's challenge will be to explain a faith that remains mysterious to many

The Scariest Guy in Washington (Profile)
With subpoena power, Henry Waxman could be the Republicans' worst nightmare

When Public Schools Aren't Color-Blind (Education)
Louisville's racial guidelines keep its schools from having too many or too few black students. Most parents like the policy. Will the Supreme Court strike it down?

WORLD

The Russian Roulette
Putin's Russia

Options for the New Secretary of Defense
With Iraq sliding into civil war, TIME looks at the tough choices facing Bob Gates

Why We Need to Talk to Iran (Global Viewpoint)

The Face of Iraq's Brutality
Exclusive: A warlord tied to some of Baghdad's worst atrocities talks to TIME about the roots of Iraq's hate

HEALTH & MEDICINE

An African Miracle (Medicine)
How a few doctors and some antiviral drugs brought a child with AIDS--and thousands like him--back from the dead

Lessons from America (Medicine / Long-Term Prognosis)

SOCIETY

Circling Back To Sewing
An old craft is gaining new appeal among the young, hip and nimble-fingered

NOTEBOOK

Numbers

They Just Won't Bow Out

Verbatim

Social Insecurity

What Daddy Couldn't Say (In the Arena)

Olympic Forecast?

Punchlines

Milestones

What's Next

Mini-Pimp is Mad

Wanna be a Rock Star? Fake It

BUSINESS

Danger Caution Ahead
Hot cars and a cool CEO saved Nissan. But has success taken the edge off the brand's potential?

Hello, Hedge Funds
Big money and big questions push hedge funds--those below-the-radar investments for the rich--to do the unthinkable: show their faces

ARTS & ENTERTAINMENT

The Revenge of the Dork (Books)
What do you do when your erudite punk-rock band stalls? Of course! Write a novel for teens

The Kramer in All of Us (Culture Complex)
As Hollywood goes nuts, maybe the audience needs to examine itself too

5 Boffo TV Boxes
These small-screen DVD collections will keep on giving long after the holiday season

The Un-Retirement of Jay-Z (Music)
Three years after quitting, he returns with an album that flirts with maturity, then loses its nerve

Ten Years Beyond Infinite (Books)
Revolutionary or unreadable? The long, strange afterlife of David Foster Wallace's Infinite Jest

First Thinking, Then Building (Architecture)
Diller and Scofidio were architects who never built anything--until they did. And it's remarkable

Kate in The Raw (Profile)
How one actress worked--and stripped--her way from stardom to respect and back again

YOUR TIME

How To Get the Party Started (Trends)

Why Women Aren't Richer (Money)

PEOPLE

People

Q & A: Wyclef Jean

10 Questions for Al Gore (Interview)

LETTERS

Read the story

My Person of the Year
To help us make this year's selection, TIME asked people who were chosen in previous years for their 2006 nominations. A sampling:

ESSAY

Let Us Now Praise Resentful Men (Cartoon)

ALSO IN THIS ISSUE

Going It Alone (Time Bonus Section December 2006: Generations)
People who have had a happy marriage may find it easier to move on after the death of their spouse

Her Second Act (Time Bonus Section December 2006: Generations)
elected to work in front of a new audience, the citizens of Detroit

Golden Gadgets (Time Bonus Section December 2006: Generations)
Cool technology is no longer just for kids. There is great stuff coming up for the aging market too

¡Viva El Gringo! (Time Bonus Section December 2006: Generations)
A couple enjoys la vida loca by retiring south of the border

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